Journal: Nature Communications

Article Title: A blood- and brain-based EWAS of smoking

doi: 10.1038/s41467-025-58357-6

Figure Lengend Snippet: Benchmarking of mCigarette against six biomarkers of smoking: EpiSmokEr 7 , GrimAge DNA methylation (DNAm) pack years 14 , and three scores developed using Generation Scotland (GS) data: BayesR score 59 , a score developed by McCartney et al. 10 and two scores developed in this study – single-site biomarker based on AHRR (cg05575921) blood DNAm level and mCigarette

Article Snippet: There were 17,865 Generation Scotland (GS) volunteers with a measure of pack years of smoking and Illumina EPIC DNAm data.

Techniques: DNA Methylation Assay, Biomarker Discovery

Journal: Nature Communications

Article Title: A blood- and brain-based EWAS of smoking

doi: 10.1038/s41467-025-58357-6

Figure Lengend Snippet: CpG methylation levels in blood (Lothian Birth Cohort 1936 baseline, n blood_DNAm = 882) and brain across different self-reported smoking categories (Lothian Birth Cohort 1936, n hippocampus_DNAm = 13). Box plots are defined as follows: the centre line represents the median (50th percentile). The box bounds indicate the interquartile range (IQR; 25th to 75th percentile). Whiskers extend to the smallest and largest values within 1.5×IQR. Source data are provided as a Source Data file.

Article Snippet: There were 17,865 Generation Scotland (GS) volunteers with a measure of pack years of smoking and Illumina EPIC DNAm data.

Techniques: CpG Methylation Assay